Methyl iodide → HCID 848831, compound

HRID 2051650Notes

Reaction equation

HRID 2051650 reaction equation
[CH3:1][C:2]1[C:3](=[O:14])[NH:4][C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([CH3:12])=[C:7]([CH3:13])[CH:6]=2.CI.[C:17](=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[CH3:17][N:4]1[C:5]2[C:10](=[CH:9][C:8]([CH3:12])=[C:7]([CH3:13])[CH:6]=2)[N:11]=[C:2]([CH3:1])[C:3]1=[O:14]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10340Sodium CarbonateHCID 2474893,6,7-trimethylquinoxalin-2-ol

Product 1

HCID 848831HCID 848831, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 3,6,7-trimethyl-2(1H)-quinoxalinone (5.0 g., 0.027 mol.), methyl iodide (15 ml.), sodium carbonate (5.0 g., 0.047 mol.) and dimethylformamide (75 ml.) were stirred at room temperature for eighteen hours, then heated at 75°-80° C. for three hours. Removal of the dimethylformamide under reduced pressure and dilution with water gave a brown solid. Crystallization from acetone (Darco) gave light tan needles. (2.85 g., m.p. 164-166°, 53%)

Workup

  1. temperatureheated at 75°-80° C. for three hours
  2. customRemoval of the dimethylformamide under reduced pressure and dilution with water
  3. customgave a brown solid
  4. customCrystallization from acetone (Darco)
  5. customgave light tan needles

Sources & evidence

ORD record
ord-1465c3f8220f46f694cf298204098fc2
Source dataset
uspto-grants-1980_01
Patent number
US04181724

Reaction notes

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