Triethylamine → 2-(2-Thienyl)ethyl methanesulphonate

HRID 2051894Notes

Reaction equation

HRID 2051894 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][OH:8].C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>ClCCl>[CH3:16][S:17]([O:8][CH2:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 794002-Thiopheneethanol

Product 1

HCID 30477232-(2-Thienyl)ethyl methanesulphonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 12.8 g of 2-(2-thienyl)ethanol and 20.2 g of triethylamine in 500 ml of dichloromethane is reacted with 12.6 g of methanesulfonyl chloride as described in Example 2 to give the product as an oil.

Sources & evidence

ORD record
ord-0be8ae0e36d64558abd63297cdaa601c
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

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