Hydrochloric Acid → HCID 23468289, compound

HRID 2051898Notes

Reaction equation

HRID 2051898 reaction equation
[C:1]1([O:11][CH2:12][CH2:13][NH:14][C:15]2[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[OH-].[K+].Cl>C(O)C.O>[C:1]1([O:11][CH2:12][CH2:13][NH:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:24][CH:25]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 23468280HCID 23468280, compound

Product 1

HCID 23468289HCID 23468289, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 12 g of ethyl p-[2-(1-naphthyloxy)-ethylamino]benzoate and 15.8 g of potassium hydroxide in 100 ml of 95% ethanol is refluxed for 3 hours. The solution is diluted with 75 ml of water and acidified with concentrated hydrochloric acid. The solid is filtered, washed with 50% ethanol and with water. Recrystallization from ethanol gives the product as crystals, mp 193°-194° C.

Workup

  1. filtrationThe solid is filtered
  2. washwashed with 50% ethanol and with water
  3. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-15f21c0bd96548e2b41579e910a1934f
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

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