Triethylamine → HCID 21480157, compound

HRID 2051923Notes

Reaction equation

HRID 2051923 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH:7]([CH3:10])[CH2:8][OH:9])=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[CH3:20][S:21]([O:9][CH2:8][CH:7]([O:6][C:5]1[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH3:10])(=[O:23])=[O:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 132594172-(4-Chlorophenoxy)propan-1-ol

Product 1

HCID 21480157HCID 21480157, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 8.5 g. of 2-(4-chlorophenoxy)-1-propanol, 9.2 g. of triethylamine and 250 ml. of dichloromethane chilled to -5° C. are added dropwise 5.7 g of methanesulfonyl chloride. The solution is allowed to stand at room temperature for 1 hour and is washed with 100 ml portions of water, 10% hydrochloric acid, saturated sodium bicarbonate and saturated sodium chloride. The organic layer is dried (magnesium sulfate) and the solvent removed under vacuum to give 11.3 g of product as an oil.

Workup

  1. washis washed with 100 ml portions of water, 10% hydrochloric acid, saturated sodium bicarbonate and saturated sodium chloride
  2. dry with materialThe organic layer is dried (magnesium sulfate)
  3. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-51318b3a1488417cbe2c16c4796a1475
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

Loading…