Ethanol → HCID 20378394, compound

HRID 2051929Notes

Reaction equation

HRID 2051929 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][CH:7]([CH3:19])[CH2:8][NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2C([O-])=O)=[CH:4][CH:3]=1.[OH-:22].[K+].[CH2:24]([OH:26])C>O.Cl.C(Cl)(Cl)Cl.CCCCCC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]([CH3:19])[CH2:8][NH:9][C:10]2[CH:11]=[CH:15][C:16]([C:24]([OH:26])=[O:22])=[CH:17][CH:18]=2)=[CH:20][CH:21]=1

Participants

8

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 131711674HCID 131711674, compound

Product 1

HCID 20378394HCID 20378394, compound

Reagents, catalysts & solvents 4

HCID 313Hydrochloric AcidSolventHCID 962WaterSolventHCID 6212ChloroformSolventHCID 8058HexaneSolvent

Procedure

A solution of 2.6 g of ethyl p-[2-(4-fluorophenoxy)propylaminobenzoate in 100 ml of 95% ethanol containing 2.7 g of potassium hydroxide was heated to reflux for 2 hours. The reaction was cooled, diluted with 100 ml of water and neutralized with 37% hydrochloric acid. The solid was collected and dried giving a white solid which was dissolved in 25 ml of chloroform and diluted with 1 ml of hexane giving a solid with a m.p. 171°-172° C.

Workup

  1. temperatureto reflux for 2 hours
  2. temperatureThe reaction was cooled
  3. customThe solid was collected
  4. customdried
  5. customgiving a white solid which

Sources & evidence

ORD record
ord-7dfb2948814a4c8285f2bfc886bd03d3
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

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