Hydrochloric Acid → HCID 178429857, compound

HRID 2052156Notes

Reaction equation

HRID 2052156 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[C:4]([N:16]2[CH2:21][CH:20]([CH3:22])[O:19][CH:18]([CH3:23])[CH2:17]2)[N:3]=1.O.[NH2:25][NH2:26].Cl>>[NH2:9][C:8]1[C:7]2[C:2](=[N:3][C:4]([N:16]3[CH2:21][CH:20]([CH3:22])[O:19][CH:18]([CH3:23])[CH2:17]3)=[CH:5][C:6]=2[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:26][N:25]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 13138508HCID 13138508, compound

Product 1

HCID 178429857HCID 178429857, compound

Procedure

3-Amino-6-(2,6-dimethyl-morpholino)-4-phenyl-1H-pyrazolo[3,4-b]-pyridine was prepared analogous to Example 1 from 2-chloro-6-(2,6-dimethyl-morpholino)-4-phenyl-3-cyano-pyridine (m.p. 165°-178° C.; mixture of isomers) and hydrazine hydrate. M.p. of the hydrochloride: 235°-238° C. (decomp.).

Sources & evidence

ORD record
ord-de5fc5dbe64640dfa489d77996c40097
Source dataset
uspto-grants-1980_01
Patent number
US04182887

Reaction notes

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