Diethylcarbamoyl chloride → N'-(5-tert-Butyl-1,2-oxazol-3-yl)-N,N-diethylurea

HRID 2052209Notes

Reaction equation

[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4][N:3]=1.[CH2:11]([N:13]([CH2:17][CH3:18])[C:14](Cl)=[O:15])[CH3:12]>>[CH2:11]([N:13]([CH2:17][CH3:18])[C:14]([NH:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4][N:3]=1)=[O:15])[CH3:12]

Participants

Reactant 2

HCID 6916Diethylcarbamoyl chloride

HCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-

Product 1

HCID 20377185N'-(5-tert-Butyl-1,2-oxazol-3-yl)-N,N-diethylureaYield 98.2%

Procedure

Using 3-amino-5-t-butylisoxazole and N,N-diethylcarbamoyl chloride, the reaction is effected as in Example 1, whereby 1,1-diethyl-3-(5-t-butyl-3-isoxazolyl)urea is obtained. Yield is 98.2%. Melting point is 122.0° to 123.5° C.

Sources & evidence

ORD record: ord-4b12ad8014da4edb9b742bbdc996555c
Source dataset: uspto-grants-1980_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04183856

Reaction notes

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