Hydrogen Bromide → HCID 135703204, compound

HRID 2052464Notes

Reaction equation

HRID 2052464 reaction equation
C(=O)C1C=CC=C(OC)C=1.[CH3:11][C:12]1[NH:16][CH:15]=[N:14][C:13]=1[CH2:17][S:18][CH2:19][CH2:20][NH:21][C:22]1[NH:27][C:26](=[O:28])[C:25]([CH2:29][C:30]2[N:31](CC3C=CC(OC)=CC=3)[CH:32]=[CH:33][N:34]=2)=[N:24][N:23]=1.C1(OC)C=CC=CC=1.Br>C(O)(=O)C>[CH3:11][C:12]1[NH:16][CH:15]=[N:14][C:13]=1[CH2:17][S:18][CH2:19][CH2:20][NH:21][C:22]1[NH:27][C:26](=[O:28])[C:25]([CH2:29][C:30]2[NH:34][CH:33]=[CH:32][N:31]=2)=[N:24][N:23]=1

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 7519AnisoleHCID 115693-MethoxybenzaldehydeHCID 137195928HCID 137195928, compound

Product 1

HCID 135703204HCID 135703204, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Substitution of 1-(4-methoxybenzyl)-2-imidazole carboxaldehyde for m-anisaldehyde in the general procedure of Example 1 leads to the production of 3-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-6-(1-(4-methyoxybenzyl)-2-imidazolylmethyl)-1,2,4-triazin-5-one, which when treated with anisole and hydrogen bromide in acetic acid gives 3-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-6-(2-imidazolylmethyl)-1,2,4-triazin-5-one

Sources & evidence

ORD record
ord-44a1dbb3607341c3abb5c9604dfd38e8
Source dataset
uspto-grants-1980_01
Patent number
US04185103

Reaction notes

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