Potassium Carbonate → HCID 131726748, compound

HRID 2052811Notes

Reaction equation

HRID 2052811 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[ClH:13].Cl.[CH2:15]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:1].[ClH:13].[CH2:15]([N:24]1[CH2:29][CH2:28][N:27]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=2)=[O:4])[CH2:26][CH2:25]1)[C:16]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:17]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2378062-Chloro-1-(4-methoxyphenyl)ethanoneHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 131726748HCID 131726748, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-chloro-1-(4-methoxyphenyl)ethanone (3 mmol), N-phenacyl piperazine dihydrochloride (3 mmol) and K2CO3 (10 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-9), 0.68 g (62%), mp 226-228° C., M+ 352.

Workup

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound (IV-9), 0.68 g (62%), mp 226-228° C., M+ 352

Sources & evidence

ORD record
ord-e1d8b6e9ce6e4d53a6369e700029e76c
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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