Potassium Carbonate → HCID 86599626, compound

HRID 2052812Notes

Reaction equation

HRID 2052812 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=[O:4].[ClH:14].Cl.[CH2:16]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:18].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:1].[ClH:14].[CH2:16]([N:25]1[CH2:30][CH2:29][N:28]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=2)=[O:4])[CH2:27][CH2:26]1)[C:17]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:18]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2642912-Chloro-1-(4-nitrophenyl)ethanoneHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 86599626HCID 86599626, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-chloro-1-(4-nitrophenyl)ethanone (3.2 mmol), N-phenacyl piperazine dihydrochloride (3 mmol), and K2CO3 (9 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-11), 0.71 g (61%), mp 204-205° C., M+ 367.

Workup

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound (IV-11), 0.71 g (61%), mp 204-205° C., M+ 367

Sources & evidence

ORD record
ord-0c4436ecbbf64582a42fa436350801cd
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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