反应详情

4-Hydroxy-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carboxylic acid amide (340 mg) was heated to reflux in ethyl acetate (2 ml) and phosphorous oxychloride (8 ml) for four hours. Solvent was evaporated under reduced pressure and the remaining residue dissolved in ethyl acetate (30 ml) and washed with saturated sodium chloride (20 ml). Organics were separated, dried over sodium sulphate and solvent was removed to yield product 4-chloro-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile (362 mg) as a brown solid. This product was used for next step without further purification.

1. customSolvent was evaporated under reduced pressure
2. dissolutionthe remaining residue dissolved in ethyl acetate (30 ml)
3. washwashed with saturated sodium chloride (20 ml)
4. customOrganics were separated
5. dry with materialdried over sodium sulphate and solvent
6. customwas removed