Phenylboronic Acid → HCID 68497053, compound

HRID 2053224Notes

Reaction equation

HRID 2053224 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([C:16]2[N:17]=[C:18](Cl)[S:19][CH:20]=2)=[O:15])[CH:8]=1)[CH3:2].[C:23]1(B(O)O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:22])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([C:16]2[N:17]=[C:18]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[S:19][CH:20]=2)=[O:15])[CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 68494747HCID 68494747, compound

Product 1

HCID 68497053HCID 68497053, compound

Procedure

The chloro thiazole (114)(80 mg, 0.24 mmol) was coupled to phenylboronic acid (32mg, 0.26 mmol) using Method E, except that the reaction mixture was heated for a total of 4 h. The crude residue was purified by column chromatography eluting with 25% EtOAc in heptane to give the title compound.

Workup

  1. temperatureexcept that the reaction mixture was heated for a total of 4 h
  2. customThe crude residue was purified by column chromatography
  3. washeluting with 25% EtOAc in heptane

Sources & evidence

ORD record
ord-ba81a6fc5c6c437796eb0673efe824d1
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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