2-Aminothiazole → HCID 178518045, compound

HRID 2053316Notes

Reaction equation

HRID 2053316 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[S:20]1[CH:24]=[CH:23][N:22]=[C:21]1[NH2:25].CCN(C(C)C)C(C)C>>[S:20]1[CH:24]=[CH:23][N:22]=[C:21]1[NH:25][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1

Participants

4

Reactant 3

HCID 21552-AminothiazoleHCID 81531DiisopropylethylamineHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518045HCID 178518045, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, thiazol-2-ylamine and DIEA to give 2-(thiazol-2-ylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 339 (MH+).

Sources & evidence

ORD record
ord-0a2791e7f4dc4614ad11020e603d159b
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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