Diisopropylethylamine → HCID 178518163, compound

HRID 2053322Notes

Reaction equation

HRID 2053322 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[OH:20][C@H:21]1[CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C@H:22]1[NH2:30].CCN(C(C)C)C(C)C>>[OH:20][C@H:21]1[CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C@H:22]1[NH:30][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanolHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518163HCID 178518163, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, (1R,2S)-(−)-2-hydroxy-indan-1-ylamine and DIEA to give 2-((1R,2S)-2-hydroxy-indan-1-ylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 388 (MH+).

Sources & evidence

ORD record
ord-8c8234f3658e412ab277a29bc32a7112
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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