Diisopropylethylamine → HCID 178518193, compound

HRID 2053325Notes

Reaction equation

HRID 2053325 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[CH:20]1[C:25]([C@@H:26]([NH2:29])[CH2:27][OH:28])=[CH:24][CH:23]=[C:22]([F:30])[CH:21]=1.CCN(C(C)C)C(C)C>>[F:30][C:22]1[CH:21]=[CH:20][C:25]([C@@H:26]([NH:29][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][CH:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)[CH2:27][OH:28])=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 10583003(R)-2-Amino-2-(4-fluorophenyl)ethanolHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518193HCID 178518193, compound

Procedure

Then the similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, (R)-4-fluoro-phenylglycinol and DIEA to give 2-[(R)-1-(4-fluoro-phenyl)-2-hydroxy-ethylamino]-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 394 (MH+).

Sources & evidence

ORD record
ord-90f85f49fcbc498b9e2e6cff9e9397ea
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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