Phenylglycine, D- → HCID 178518198, compound

HRID 2053341Notes

Reaction equation

HRID 2053341 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[CH:20]1[CH:25]=[CH:24][C:23]([C@@H:26]([NH2:30])[C:27]([OH:29])=[O:28])=[CH:22][CH:21]=1.CCN(C(C)C)C(C)C>>[O:8]=[C:6]1[N:7]=[C:3]([NH:30][C@H:26]([C:23]2[CH:24]=[CH:25][CH:20]=[CH:21][CH:22]=2)[C:27]([OH:29])=[O:28])[S:4]/[C:5]/1=[CH:9]\[C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]=[CH:15][CH:14]=[CH:13]2

Participants

4

Reactant 3

HCID 70134Phenylglycine, D-HCID 81531DiisopropylethylamineHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518198HCID 178518198, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, D-phenylglycine and DIEA to give (R)-{4-oxo-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-4,5-dihydro-thiazol-2-ylamino}-phenyl-acetic acid. LC-MS m/e 390 (MH+).

Sources & evidence

ORD record
ord-728662028a0e47228aae2dc73d79d9d2
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

Loading…