Diisopropylethylamine → HCID 178518172, compound

HRID 2053348Notes

Reaction equation

HRID 2053348 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[OH:20][C@@H:21]1[CH2:25][CH2:24][CH2:23][C@H:22]1[NH2:26].CCN(C(C)C)C(C)C>>[OH:20][C@@H:21]1[CH2:25][CH2:24][CH2:23][C@H:22]1[NH:26][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 10464306rac-(1R,2R)-2-aminocyclopentan-1-olHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518172HCID 178518172, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, (1R,2R)-2-hydroxy-cyclopentylamine and DIEA to give 2-((1R,2R)-2-hydroxy-cyclopentylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 340 (MH+).

Sources & evidence

ORD record
ord-ad4c813fa3384e60b04c9b626c0e0c61
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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