Hydrochloric Acid → HCID 68567779, compound

HRID 2053536Notes

Reaction equation

HRID 2053536 reaction equation
[ClH:1].C(OC([N:9]1[C@H:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@H:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:11]=[C:10]1[NH:26][C:27](=[O:35])[C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)=O)(C)(C)C>CCOC(C)=O>[ClH:1].[C:14]1([C@H:13]2[C@@H:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:11][C:10]([NH:26][C:27](=[O:35])[C:28]3[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=3)=[N:9]2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68569865HCID 68569865, compound

Product 1

HCID 68567779HCID 68567779, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride is bubbled into a solution of 125 (123 mg, 0.267 mmol) in EtOAc (20 mL) for 1 min, and the solution is stirred at RT overnight. The solvent is removed by rotary evaporation, and the residue is triturated with Et2O to give 50 mg of the product 126. 1H NMR (DMSO-d6) δ 12.9 (s, 1H), 9.70 (s, 2H), 8.35-8.15 (m, 2H), 7.60-7.40 (m, 2H), 7.20-6.90 (m, 10), 5.70 (s, 2H); LC/MS: 3.20 m/z 360 (M++1).

Workup

  1. customThe solvent is removed by rotary evaporation
  2. customthe residue is triturated with Et2O

Sources & evidence

ORD record
ord-93ccb15c879645a1a941f3f1b6b4ef67
Source dataset
uspto-grants-2008_02
Patent number
US07326792B2

Reaction notes

Loading…