N'-tert-butoxycarbonyl-C-(5-chloro-1H-benzimidazol-2-yl)methylamine → HCID 178510549, compound

HRID 2053756Notes

Reaction equation

HRID 2053756 reaction equation
C(OC([N:8]1[C:12]2[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=2[NH:10][CH:9]1[CH2:18][NH2:19])=O)(C)(C)C>Cl>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]2[NH:10][C:9]([CH2:18][NH2:19])=[N:8][C:12]=2[CH:13]=1

Participants

3

Reactant 1

HCID 69311165N'-tert-butoxycarbonyl-C-(5-chloro-1H-benzimidazol-2-yl)methylamine

Product 1

HCID 178510549HCID 178510549, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4.62 g (16.398 mmol) N′-tert-butoxycarbonyl-C-(5-chloro-1H-benzimidazol-2-yl)methylamine are dissolved in 100 mL saturated ethanolic hydrogen chloride solution and stirred for 2 hours at ambient temperature. Then all the volatile constituents are removed under reduced pressure and the crude product is further reacted. Yield: quantitative; Rf value: 0.35 (silica gel; petroleum ether/ethyl acetate=8:2).

Workup

  1. customThen all the volatile constituents are removed under reduced pressure
  2. customthe crude product is further reacted

Sources & evidence

ORD record
ord-7478f4d72a2244f0bcd4683b650e5575
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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