反应详情

4.62 g (16.398 mmol) N′-tert-butoxycarbonyl-C-(5-chloro-1H-benzimidazol-2-yl)methylamine are dissolved in 100 mL saturated ethanolic hydrogen chloride solution and stirred for 2 hours at ambient temperature. Then all the volatile constituents are removed under reduced pressure and the crude product is further reacted. Yield: quantitative; Rf value: 0.35 (silica gel; petroleum ether/ethyl acetate=8:2).

1. customThen all the volatile constituents are removed under reduced pressure
2. customthe crude product is further reacted