Dichloromethane ethanol → HCID 43114481, compound

HRID 2053758Notes

Reaction equation

HRID 2053758 reaction equation
C([NH:4][CH:5]([C:13]1[NH:14][C:15]2[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:16]=2[N:17]=1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=O)C.ClCCl.C(O)C>Cl.CO>[Cl:22][C:20]1[CH:19]=[CH:18][C:16]2[N:17]=[C:13]([CH:5]([NH2:4])[CH2:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)[NH:14][C:15]=2[CH:21]=1

Participants

5

Reactant 2

HCID 21584144Dichloromethane ethanolHCID 69314702HCID 69314702, compound

Product 1

HCID 43114481HCID 43114481, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

1.35 g (4.302 mmol) of rac.-N-acetyl-1-(5-chlorobenzimidazol-2-yl)-2-phenylethylamine is placed in a mixture of 20 mL of 4 molar hydrochloric acid and 15 mL of methanol and the mixture is refluxed for 2 hours. Then all the volatile constituents are removed under reduced pressure. The crude product is further reacted directly. Rf value: 0.50 (silica gel; dichloromethane/ethanol=8:2).

Workup

  1. temperaturethe mixture is refluxed for 2 hours
  2. customThen all the volatile constituents are removed under reduced pressure
  3. customThe crude product is further reacted directly

Sources & evidence

ORD record
ord-067e72a1f7064a1e999bd17879db5745
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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