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HRID2053768

反应详情

EQUATION

反应方程式

HRID 2053768 的结构方程式

REACTANTS

反应物

5
结构：ClCl
HCID24526

Chlorine

Cl2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：N#Cc1ccc(C(=O)O)c(Cl)c1
HCID231894

未命名化合物

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：CC(C)(C)OC(=O)NCC1CCCN1
HCID21834643

tert-Butyl [(pyrrolidin-2-yl)methyl]carbamate

C10H20N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NCC1CCCN1C(=O)c1ccc(C#N)cc1Cl
HCID69309927

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example I d from 2-chloro-4-cyanobenzoic acid, TBTU, N,N-diisopropylethylamine, and rac.-2-(N-tert-butoxycarbonylaminomethyl)pyrrolidine in tetrahydrofuran. Yield: quantitative; Rf value: 0.52 (silica gel; dichloromethane/ethanol=95:5); C18H22ClN3O3 (363.85); mass spectrum: (M+H)+=364/366 (chlorine isotope).

WORKUP

后处理

  1. customPrepared analogously to Example I