反应详情

0.33 g (4.8 mmol) of hydroxylamine hydrochloride and then 0.9 mL (4.6 mmol) of triethylamine are added to a solution of 0.83 g (4.34 mmol) of 6-chloroquinoline-2-carbaldehyde in 20 mL of DMF/ethanol (v/v 1:1). The reaction mixture is stirred for 16 hours at ambient temperature; then it is poured into water. The precipitated solid is filtered off and dried. Yield: 0.79 g (88% of theory); Rf value: 0.73 (silica gel; dichloromethane/methanol=9:1); C10H7ClN2O (206.63); mass spectrum: (M+H)+=407/209 (chlorine isotope).

1. filtrationThe precipitated solid is filtered off
2. customdried