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HRID2053886

反应详情

EQUATION

反应方程式

HRID 2053886 的结构方程式

REACTANTS

反应物

5
结构：ClCl
HCID24526

Chlorine

Cl2

2 次

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：O=C1CNCCN1
HCID231360

Piperazin-2-one

C4H8N2O

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：C[C@H](NC(=O)c1ccc(C(=O)O)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
HCID178462084

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)c1ccc(C(=O)N2CCNC(=O)C2)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
HCID178462077

未命名化合物

收率 58%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 1g from 2-chloro-4-{N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and piperazin-2-one in tetrahydrofuran. Yield: 58%; Rf value: 0.22 (silica gel; dichloromethane/ethanol=9:1); C21H19Cl2N5O3 (460.32); mass spectrum: (M+H)+=460/462/464 (chlorine isotope) and (M−H)−=458/460/462 (chlorine isotope).