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HRID2053903

反应详情

EQUATION

反应方程式

HRID 2053903 的结构方程式

REACTANTS

反应物

5
结构：ClCl
HCID24526

Chlorine

Cl2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：COc1cc(C(=O)O)ccc1C(=O)N1CCCC1
HCID69315318

未命名化合物

结构：C[C@H](N)c1nc2cc(Cl)ccc2[nH]1
HCID178461859

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(C(=O)N[C@@H](C)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1
HCID178492726

未命名化合物

收率 29%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 1g from 3-methoxy-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: 29%; Rf value: 0.31 (silica gel; dichloromethane/ethanol=9:1); C22H23ClN4O3 (426.90); mass spectrum: (M+H)+=427/429 (chlorine isotope).