Trifluoroacetic acid → HCID 178427172, compound

HRID 2053959Notes

Reaction equation

HRID 2053959 reaction equation
[Cl:1][C:2]1[CH:46]=[CH:45][C:5]2[NH:6][C:7]([C@@H:9]([NH:28][C:29](=[O:44])[C:30]3[CH:35]=[CH:34][C:33]([C:36]([N:38]4[CH2:42][CH2:41][CH2:40][CH2:39]4)=[O:37])=[C:32]([CH3:43])[CH:31]=3)[CH2:10][CH2:11][C:12]([N:14]3[CH2:18][CH2:17][CH2:16][C@@H:15]3[CH2:19][NH:20]C(OC(C)(C)C)=O)=[O:13])=[N:8][C:4]=2[CH:3]=1.FC(F)(F)C(O)=O.ClCl>C(OCC)(=O)C>[Cl:1][C:2]1[CH:46]=[CH:45][C:5]2[NH:6][C:7]([C@@H:9]([NH:28][C:29](=[O:44])[C:30]3[CH:35]=[CH:34][C:33]([C:36]([N:38]4[CH2:42][CH2:41][CH2:40][CH2:39]4)=[O:37])=[C:32]([CH3:43])[CH:31]=3)[CH2:10][CH2:11][C:12]([N:14]3[CH2:18][CH2:17][CH2:16][C@@H:15]3[CH2:19][NH2:20])=[O:13])=[N:8][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 24526ChlorineHCID 178427174HCID 178427174, compound

Product 1

HCID 178427172HCID 178427172, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared from N-{(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-[(2R)-2-tert-butoxycarbonylaminomethylpyrrolidin-1-ylcarbonyl]propyl}-3-methyl-4-(pyrrolidin 1-ylcarbonyl)benzamide followed by treatment with trifluoroacetic acid analogously to Example 17. Yield: 100%; Rf value: <0.1 (silica gel; ethyl acetate); C29H35ClN6O5 (551.09); mass spectrum: (M+H)+=551/553 (chlorine isotope).

Sources & evidence

ORD record
ord-4d64f172f0334374aec30cef56af0830
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

Loading…