huagongshe.com
HRID2053960

反应详情

EQUATION

反应方程式

HRID 2053960 的结构方程式

REACTANTS

反应物

6
结构：ClCl
HCID24526

Chlorine

Cl2

2 次

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：NCc1cc2cc(Cl)ccc2[nH]1
HCID4689978

(5-chloro-1H-indol-2-yl)methanamine

C9H9ClN2

结构：Cc1cc(C(=O)O)ccc1C(=O)N1CCCC1
HCID12068686

未命名化合物

结构：CCO.CCOC(C)=O.N
HCID86587043

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C(=O)NCc2cc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1
HCID59655287

未命名化合物

收率 31%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and C-(5-chloro-1H-indol-2-yl)methylamine in dimethylformamide. Yield: 31%; Rf value: 0.61 (silica gel; ethyl acetate/ethanol/ammonia=9:1:0.1); C22H22ClN3O2 (395.89); mass spectrum: (M+H)+=396/398 (chlorine isotope) and (M−H)−=394/396 (chlorine isotope).