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HRID2053962

反应详情

EQUATION

反应方程式

HRID 2053962 的结构方程式

REACTANTS

反应物

5
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：ClCl
HCID24526

Chlorine

Cl2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CCNC1CCN(C(=O)OC(C)(C)C)CC1
HCID18374730

tert-Butyl 4-(ethylamino)piperidine-1-carboxylate

C12H24N2O2

结构：CC(NC(=O)c1ccc(C(=O)O)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
HCID178464831

未命名化合物

PRODUCTS

生成物

1
结构：CCN(C(=O)c1ccc(C(=O)NC(C)c2nc3cc(Cl)ccc3[nH]2)cc1Cl)C1CCNCC1
HCID178464828

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Prepared analogously to Example 1d from 2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, tert-butyl 4-ethylaminopiperidin-1-ylcarboxylate, PFTU, and diisopropylethylamine in DMSO at ambient temperature and subsequent reaction with trifluoroacetic acid analogously to Example 17. HPLC-MS results: retention time: 3.87 minutes; C24H27Cl2N5O2 (488.42); mass spectrum: (M−H)−=487/489/491 (chlorine isotope).

WORKUP

后处理

  1. customHPLC-MS results