反应详情

3.9 g (0.0123 mol) of [1-(3-phenylxanthin-1-yl)methyl]dimethylphosphine oxide (Example 70) were stirred at 70° C. for 6 hours with 1.33 g (0.0147 mol) of chloromethylcyclopropane and 2 g of potassium carbonate. The solution was filtered and concentrated, and the residue which remained was chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1).

1. filtrationThe solution was filtered
2. concentrationconcentrated
3. customthe residue which remained was chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1)