Hydrochloric Acid → 8-Chloro-3-(4-methoxy-benzyl)-8-(3-methoxy-phenyl)-3-aza-bicyclo[3.2.1]octane

HRID 205405Notes

Reaction equation

HRID 205405 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]2[CH2:9][CH:10]3[CH2:11][CH2:12][CH:13]([CH2:14]2)[C:15]3([OH:16])[c:17]2[cH:18][c:19]([O:23][CH3:24])[cH:20][cH:21][cH:22]2)[cH:25][cH:26]1.[CH3:28][CH2:29][O:30][C:31]([CH3:32])=[O:33].[CH3:34][CH2:35][O:36][C:37]([CH3:38])=[O:39].[ClH:27]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]2[CH2:9][CH:10]3[CH2:11][CH2:12][CH:13]([CH2:14]2)[C:15]3([c:17]2[cH:18][c:19]([O:23][CH3:24])[cH:20][cH:21][cH:22]2)[Cl:27])[cH:25][cH:26]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl Acetate2×HCID 694310753-(4-Methoxy-benzyl)-8-(3-methoxy-phenyl)-3-aza-bicyclo[3.2.1]octan-8-ol

Product 1

HCID 694314818-Chloro-3-(4-methoxy-benzyl)-8-(3-methoxy-phenyl)-3-aza-bicyclo[3.2.1]octane

Sources & evidence

ORD record
ord-3d48c4ea2a8b4d4185faf4b35193c32d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…