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HRID2054053

反应详情

EQUATION

反应方程式

HRID 2054053 的结构方程式

REACTANTS

反应物

5
结构：ClCl
HCID24526

Chlorine

Cl2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：O=C(O)c1ccc(C(=O)N2CC=CC2)c(C(F)(F)F)c1
HCID69312632

未命名化合物

结构：N[C@@H](CO)c1nc2cc(Cl)ccc2[nH]1
HCID178511833

未命名化合物

PRODUCTS

生成物

1
结构：O=C(N[C@@H](CO)c1nc2cc(Cl)ccc2[nH]1)c1ccc(C(=O)N2CC=CC2)c(C(F)(F)F)c1
HCID178523886

未命名化合物

收率 20%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 1g from 4-(2,5-dihydropyrrol-1-ylcarbonyl)-3-trifluoromethylbenzoic acid, TBTU, diisopropylethylamine, and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-hydroxyethylamine in tetrahydrofuran. Yield: 20%; Rf value: 0.43 (silica gel: dichloromethane/ethanol=9:1); C22H18ClF3N4O3 (478.856); mass spectrum: (M+H)+=479/481 (chlorine isotope).