huagongshe.com
HRID2054062

反应详情

EQUATION

反应方程式

HRID 2054062 的结构方程式

REACTANTS

反应物

4
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：CCCc1nc2c(=O)[nH]ccc2n1-c1ccc(C(=O)O)cc1C(F)(F)F
HCID69312597

未命名化合物

结构：CSCC[C@H](N)c1nc2cc(Cl)ccc2[nH]1
HCID178503691

未命名化合物

PRODUCTS

生成物

1
结构：CCCc1nc2c(=O)[nH]ccc2n1-c1ccc(C(=O)N[C@@H](CCSC)c2nc3cc(Cl)ccc3[nH]2)cc1C(F)(F)F
HCID178439988

未命名化合物

收率 40%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 1 g from 4-(4-oxo-2-propyl-4,5-dihydroimidazo[4,5-c]-pyridin-1-yl)-3-trifluoromethylbenzoic acid, TBTU, diisopropylethylamine, and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfanylpropylamine in tetrahydrofuran. Yield: 40%; Rf value: 0.35 (silica gel: dichloromethane/ethanol=9:1); C28H26ClF3N6O2S (603.066).