Chlorine → HCID 178432302, compound

HRID 2054063Notes

Reaction equation

HRID 2054063 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][C:8]=2[C:16]([F:19])([F:18])[F:17])[C:5]2[CH2:20][CH2:21][CH2:22][C:4]=2[N:3]=1.C(N(C(C)C)CC)(C)C.[Cl:32][C:33]1[CH:44]=[CH:43][C:36]2[NH:37][C:38]([C@@H:40]([NH2:42])[CH3:41])=[N:39][C:35]=2[CH:34]=1.ClCl>CN(C)C=O>[Cl:32][C:33]1[CH:44]=[CH:43][C:36]2[NH:37][C:38]([C@@H:40]([NH:42][C:11](=[O:13])[C:10]3[CH:14]=[CH:15][C:7]([N:6]4[C:5]5[CH2:20][CH2:21][CH2:22][C:4]=5[N:3]=[C:2]4[CH3:1])=[C:8]([C:16]([F:19])([F:17])[F:18])[CH:9]=3)[CH3:41])=[N:39][C:35]=2[CH:34]=1

Participants

6

Reactant 4

HCID 24526ChlorineHCID 81531DiisopropylethylamineHCID 42034613(S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamineHCID 69311159HCID 69311159, compound

Product 1

HCID 178432302HCID 178432302, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1d from 4-(2-methyl-5,6-dihydro-4H-cyclopentaimidazol-1-yl)-3-trifluoromethylbenzoic acid, PFTU, diisopropylethylamine, and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in dimethylformamide. Yield: 64%; C24H21ClF3N5O (487.911); mass spectrum: (M−H)−=486/488 (chlorine isotope).

Sources & evidence

ORD record
ord-762c7f0743274a6ab3ed9c707582fc7a
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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