Sodium Hydroxide → HCID 178464794, compound

HRID 2054067Notes

Reaction equation

HRID 2054067 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][C:22]=1[C:23]([N:25]1[CH2:29][CH2:28][CH2:27][CH:26]1[C:30]([O:32]C)=[O:31])=[O:24])[C:5]([NH:7][CH:8]([C:10]1[NH:14][C:13]2[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:12]=2[N:11]=1)[CH3:9])=[O:6].[OH-].[Na+].ClCl>C(O)(C)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][C:22]=1[C:23]([N:25]1[CH2:29][CH2:28][CH2:27][CH:26]1[C:30]([OH:32])=[O:31])=[O:24])[C:5]([NH:7][CH:8]([C:10]1[NH:14][C:13]2[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:12]=2[N:11]=1)[CH3:9])=[O:6]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24526ChlorineHCID 178498064HCID 178498064, compound

Product 1

HCID 178464794HCID 178464794, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Prepared analogously to Example 19b from rac.-3-chloro-N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-4-(2-methoxycarbonylpyrrolidin-1-ylcarbonyl)benzamide, and sodium hydroxide solution in isopropanol. Yield: 85%; C22H20Cl2N4O4 (475.33); mass spectrum: (M+H)+=475/477/479 (chlorine isotope).

Sources & evidence

ORD record
ord-9d7fb4be814a4263bc3303956a79ef15
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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