Chlorine → HCID 178427130, compound

HRID 2054092Notes

Reaction equation

HRID 2054092 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([N:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)=[O:12])[C:5]([OH:7])=O.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(C(C)C)CC)(C)C.[Cl:49][C:50]1[CH:69]=[CH:68][C:53]2[NH:54][C:55]([C@@H:57]([NH2:67])[CH2:58][C:59]3[CH:64]=[C:63]([F:65])[CH:62]=[C:61]([F:66])[CH:60]=3)=[N:56][C:52]=2[CH:51]=1.ClCl>O1CCCC1.ClCCl.C(O)C>[Cl:49][C:50]1[CH:69]=[CH:68][C:53]2[NH:54][C:55]([C@@H:57]([NH:67][C:5](=[O:7])[C:4]3[CH:8]=[CH:9][C:10]([C:11]([N:13]4[CH2:17][CH2:16][CH2:15][CH2:14]4)=[O:12])=[C:2]([CH3:1])[CH:3]=3)[CH2:58][C:59]3[CH:60]=[C:61]([F:66])[CH:62]=[C:63]([F:65])[CH:64]=3)=[N:56][C:52]=2[CH:51]=1

Participants

8

Reactant 5

HCID 24526ChlorineHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 120686863-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acidHCID 178511776HCID 178511776, compound

Product 1

HCID 178427130HCID 178427130, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-2-(3,5-difluorophenyl)ethylamine in tetrahydrofuran. Yield: %; Rf value: 0.43 (silica gel: dichloromethane/ethanol=9:1); C28H25ClF2N4O2 (522.99); mass spectrum: (M+H)+=523/525 (chlorine isotope).

Sources & evidence

ORD record
ord-4c1af1dd875840c19f6c919e921dc600
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

Loading…