huagongshe.com
HRID2054100

反应详情

EQUATION

反应方程式

HRID 2054100 的结构方程式

REACTANTS

反应物

5
结构：BrBr
HCID24408

Bromine

Br2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：Cc1cc(C(=O)O)ccc1C(=O)N1CCCC1
HCID12068686

未命名化合物

结构：N[C@@H](CO)c1nc2cc(Br)ccc2[nH]1
HCID178511832

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C(=O)N[C@@H](CO)c2nc3cc(Br)ccc3[nH]2)ccc1C(=O)N1CCCC1
HCID178427199

未命名化合物

收率 43%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxyethylamine in tetrahydrofuran. Yield: 43%; Rf value: 0.23 (silica gel: dichloromethane/ethanol=95:5); C22H23BrN4O3 (471.36); mass spectrum: (M+H)+=471/473 (bromine isotope). The Examples that follow describe the preparation of pharmaceutical formulations which contain as active substance any desired compound of general formula (1).

WORKUP

后处理

  1. customthe preparation of pharmaceutical formulations which