Tetrahydrofuran → (+/-)-1-(5-chloro-3-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indol-7-yl)ethyl 2,2,2-trichloroacetimidate

HRID 205422Notes

Reaction equation

HRID 205422 reaction equation
[CH2:1]1[CH2:2][CH2:3][C:4]2=[N:9][CH2:8][CH2:7][CH2:6][N:5]2[CH2:10][CH2:11]1.[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[Cl:12][c:13]1[cH:14][c:15]2[c:16]([C:33]#[N:34])[cH:17][n:18]([CH2:25][O:26][CH2:27][CH2:28][Si:29]([CH3:30])([CH3:31])[CH3:32])[c:19]2[c:20]([CH:22]([CH3:23])[OH:24])[cH:21]1.[Cl:35][C:36]([C:37]#[N:38])([Cl:39])[Cl:40]>>[Cl:12][c:13]1[cH:14][c:15]2[c:16]([C:33]#[N:34])[cH:17][n:18]([CH2:25][O:26][CH2:27][CH2:28][Si:29]([CH3:30])([CH3:31])[CH3:32])[c:19]2[c:20]([CH:22]([CH3:23])[O:24][C:37]([C:36]([Cl:35])([Cl:39])[Cl:40])=[NH:38])[cH:21]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11011TrichloroacetonitrileHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 57546168(+/-)-5-chloro-7-(1-hydroxyethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole-3-carbonitrile

Product 1

HCID 57546157(+/-)-1-(5-chloro-3-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indol-7-yl)ethyl 2,2,2-trichloroacetimidate

Sources & evidence

ORD record
ord-e1368c9040ac47129e170767767cb127
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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