Hydrazine hydrate (1:1) → HCID 59655794, compound

HRID 2054345Notes

Reaction equation

HRID 2054345 reaction equation
NCC(C1NC2C(C=1)=CC=CN=2)OC1CCCCO1.[Cl:20][C:21]1[CH:29]=[CH:28][N:27]=[C:26]2[C:22]=1[CH:23]=[C:24]([CH:30]([O:43][CH:44]1[CH2:49][CH2:48][CH2:47][CH2:46][O:45]1)[CH2:31][N:32]1C(=O)C3=CC=CC=C3C1=O)[NH:25]2.NN.O>CCO>[NH2:32][CH2:31][CH:30]([C:24]1[NH:25][C:26]2[C:22]([CH:23]=1)=[C:21]([Cl:20])[CH:29]=[CH:28][N:27]=2)[O:43][CH:44]1[CH2:49][CH2:48][CH2:47][CH2:46][O:45]1

Participants

5

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 11379978HCID 11379978, compoundHCID 59655772HCID 59655772, compound

Product 1

HCID 59655794HCID 59655794, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the same procedure as for 9a, from 4-Chloro-2-[2-phthalimido-1-(2,3,5,6-tetrahydropyran-2-yl)oxyethyl]-7-azaindole (950 mg, 2.2 mmol) in EtOH (50 ml) and NH2NH2.H2O (250 μl, 4.4 mmol). After a reaction time of 3 h. a diastereomeric mixture (1:1) of 9c (640 mg, 97%/o) was obtained.

Sources & evidence

ORD record
ord-b42585eb7dde4b778bda71ab4f61421d
Source dataset
uspto-grants-2008_02
Patent number
US07329666B2

Reaction notes

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