Oxalyl chloride → HCID 86596519, compound

HRID 2054507Notes

Reaction equation

HRID 2054507 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14](C(O)=O)[CH:15]=2)[C:10]([CH3:20])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)[C:22]([Cl:24])=[O:23]>ClCCl.CN(C)C=O>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([CH3:20])([C:22]([Cl:24])=[O:23])[NH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 22663189HCID 22663189, compound

Product 1

HCID 86596519HCID 86596519, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of 1-benzyl-3-methyl-indazole-6-carboxylic acid [0.15 g, Reference Example 28(o)] in dichloromethane (20 ml) was treated with dimethylformamide (2 drops) then with oxalyl chloride (1.69 ml). After stirring for 2 hours the reaction mixture was evaporated and the residue was dried under high vacuum to give the title compound (0.16 g) which was used without further purification.

Workup

  1. customwas evaporated
  2. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-b147c909e35c41ec9c3d7df962c54178
Source dataset
uspto-grants-2008_02
Patent number
US07329675B2

Reaction notes

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