Hydrochloric Acid → HCID 69298551, compound

HRID 2054598Notes

Reaction equation

HRID 2054598 reaction equation
[OH-].[Na+].C[O:4][C:5](=[O:28])[CH2:6][CH2:7][C:8]([C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([Cl:19])[CH:17]=2)[N:12]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)[CH:11]=1)=[O:9].Cl>O1CCCC1.CO.O>[Br:27][C:24]1[CH:23]=[CH:22][C:21]([CH2:20][N:12]2[C:13]3[C:18](=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([C:8](=[O:9])[CH2:7][CH2:6][C:5]([OH:28])=[O:4])=[CH:11]2)=[CH:26][CH:25]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69298516HCID 69298516, compound

Product 1

HCID 69298551HCID 69298551, compoundYield 95.1%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

2N Sodium hydroxide solution (0.21 mL, 0.42 mmol) was added dropwise to a stirred solution of methyl-4-[1-(4-bromobenzyl)-5-chloro-1H-indol-3-yl]-4-oxo-butyrate (59 mg, 0.14 mmol) in tetrahydrofuran (5 mL) and methanol (1 mL). The clear reaction mixture was stirred at room temperature until the reaction was complete (TLC control), and then diluted with water (10 mL), and acidified to pH 3 with 2N hydrochloric acid. The reaction mixture was extracted with ethyl acetate (2×20 mL). The combined extract was washed with water, brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. Purification of the product by flash column chromatography, using 5% methanol in methylene chloride as eluent, afforded the title compound as a white solid (56 mg, 95%): Rf: 0.30 (5% methanol in dichloromethane); 1H NMR (DMSO-d6, 300 MHz) δ 12.1 (1H, br s, OH), 8.67 (1H, s, ArH), 8.13 (1H, d, J=2 Hz, ArH), 7.52 (3H, m, ArH), 7.24 (3H, m, ArH), 5.48 (2H, s, CH2N), 3.12 (2H, t, J=7 Hz, CH2CO), 2.57 (2H, t, J=7 Hz, CH2CO).

Workup

  1. extractionThe reaction mixture was extracted with ethyl acetate (2×20 mL)
  2. extractionThe combined extract
  3. washwas washed with water, brine
  4. dry with materialdried over anhydrous MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customPurification of the product by flash column chromatography

Sources & evidence

ORD record
ord-71451368f63f48e490f35fbe26e11fb6
Source dataset
uspto-grants-2008_02
Patent number
US07329680B2

Reaction notes

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