Triethylamine → HCID 21938103, compound

HRID 2054617Notes

Reaction equation

HRID 2054617 reaction equation
[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:35][N:36]=[C:37]=[O:38]>ClCCl>[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:37](=[O:38])[NH:36][CH3:35])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 8471Triethylamine2×HCID 12228Methyl Isocyanate2×HCID 21938176HCID 21938176, compound

Product 1

HCID 21938103HCID 21938103, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

100 mg of 4-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]butan-1-ol was dissolved in 4 ml of dichloromethane, mixed with 0.1 ml of triethylamine and 20 mg of methyl isocyanate and stirred for 15 hours. Another 0.1 ml of triethylamine and 20 mg of methyl isocyanate were added, allowed to stir for 20 hours, and then concentrated by evaporation in a vacuum. The residue was purified using chromatography on silica gel.

Workup

  1. stirringto stir for 20 hours
  2. concentrationconcentrated by evaporation in a vacuum
  3. customThe residue was purified

Sources & evidence

ORD record
ord-18f38ce8e50a46e1aeeeee3dbe46fe71
Source dataset
uspto-grants-2008_02
Patent number
US07329679B2

Reaction notes

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