Hydrogen Peroxide → HCID 10294358, compound

HRID 2054618Notes

Reaction equation

HRID 2054618 reaction equation
C(=O)([O-])[O-:2].[K+].[K+].OO.[C:9]1([N:15]2[C:19]3[CH:20]=[C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]#[N:31])[CH:22]=[CH:23][C:18]=3[N:17]=[C:16]2[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CO>[C:9]1([N:15]2[C:19]3[CH:20]=[C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([NH2:31])=[O:2])[CH:22]=[CH:23][C:18]=3[N:17]=[C:16]2[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 21937973HCID 21937973, compound

Product 1

HCID 10294358HCID 10294358, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

18 mg of potassium carbonate and 40 μl of 30% hydrogen peroxide solution were added to a solution of 50 mg of 6-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]hexanonitrile in 1 ml of methanol, and it was allowed to stir for 24 hours. Then, ice-cold aqueous sodium thiosulfate solution was stirred in and extracted three times with ethyl acetate. After drying on sodium sulfate, it was concentrated by evaporation in a vacuum, and the residue was chromatographed on silica gel.

Workup

  1. stirringThen, ice-cold aqueous sodium thiosulfate solution was stirred in and
  2. extractionextracted three times with ethyl acetate
  3. customAfter drying on sodium sulfate, it
  4. concentrationwas concentrated by evaporation in a vacuum
  5. customthe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-be1b324f35c7422297bef4cd1a5171d0
Source dataset
uspto-grants-2008_02
Patent number
US07329679B2

Reaction notes

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