Hydrochloric Acid → {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}quinolin-8-ylmethanone, hydrochloride

HRID 2054696Notes

Reaction equation

HRID 2054696 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[CH:20][CH:21]=[C:22]4[C:27]=3[N:26]=[CH:25][CH:24]=[CH:23]4)=[O:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[ClH:28]>CC(C)=O>[ClH:28].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[CH:20][CH:21]=[C:22]4[C:27]=3[N:26]=[CH:25][CH:24]=[CH:23]4)=[O:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10155608{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}quinolin-8-ylmethanone

Product 1

HCID 131726768{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}quinolin-8-ylmethanone, hydrochloride

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Salt formation by reaction of a solution of {4-[2-(4-fluorophenyl)ethyl]-piperazin-1-yl}quinolin-8-ylmethanone in 30 ml of acetone with 0.2 ml of ethanolic hydrochloric acid gives {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}quinolin-8-ylmethanone, hydrochloride, m.p. 219-220.5°.

Sources & evidence

ORD record
ord-a085f8b167d342ea9091a8b9998af425
Source dataset
uspto-grants-2008_02
Patent number
US07329749B2

Reaction notes

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