1-Amino-4-methylpiperazine → [5-[5-Amino-6-[(2-chloro-3,6-difluorophenyl)methoxy]pyrazin-2-yl]thiophen-2-yl]-(4-methylpiperazin-1-yl)methanone

HRID 205487Notes

Reaction equation

HRID 205487 reaction equation
[CH3:27][N:28]1[CH2:29][CH2:30][N:31]([NH2:34])[CH2:32][CH2:33]1.[NH2:1][c:2]1[n:3][cH:4][c:5](-[c:19]2[cH:20][cH:21][c:22]([C:24](=[O:25])[OH:26])[s:23]2)[n:6][c:7]1[O:8][CH2:9][c:10]1[c:11]([Cl:18])[c:12]([F:17])[cH:13][cH:14][c:15]1[F:16]>>[NH2:1][c:2]1[n:3][cH:4][c:5](-[c:19]2[cH:20][cH:21][c:22]([C:24](=[O:26])[N:31]3[CH2:30][CH2:29][N:28]([CH3:27])[CH2:33][CH2:32]3)[s:23]2)[n:6][c:7]1[O:8][CH2:9][c:10]1[c:11]([Cl:18])[c:12]([F:17])[cH:13][cH:14][c:15]1[F:16]

Participants

3

Reactant 2

HCID 813491-Amino-4-methylpiperazineHCID 211113135-[5-Amino-6-[(2-chloro-3,6-difluorophenyl)methoxy]pyrazin-2-yl]thiophene-2-carboxylic acid

Product 1

HCID 21111311[5-[5-Amino-6-[(2-chloro-3,6-difluorophenyl)methoxy]pyrazin-2-yl]thiophen-2-yl]-(4-methylpiperazin-1-yl)methanone

Sources & evidence

ORD record
ord-fdaf2af932d84db3a67355156d6cbd2b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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