2-Bromopropiophenone → HCID 69203642, compound

HRID 2055215Notes

Reaction equation

HRID 2055215 reaction equation
[ClH:1].Cl.[Cl:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1.Br[CH:18]([CH3:27])[C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:20]>C(O)C>[ClH:3].[ClH:1].[Cl:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:18]([C:19](=[O:20])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH3:27])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 164522-BromopropiophenoneHCID 20437426HCID 20437426, compound

Product 1

HCID 69203642HCID 69203642, compoundYield 146.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-(4-chlorobenzyl)piperazine dihydrochloride (5 g, 20 mmol), anhydrous KHCO3 (70 mmol) and 2-bromo-1-phenylpropan-1-one (3.96 ml, 26 mmol) in 40 ml of anhydrous ethanol was refluxed for 8 hours, and then treated according to general preparation 2 to give 6.1 g of compound (IV-2), yield 59.51%, mp 260-262° C. M+ 342.

Workup

  1. temperaturewas refluxed for 8 hours
  2. additiontreated
  3. customaccording to general preparation 2

Sources & evidence

ORD record
ord-234f7227633c47a1abdb423179b67432
Source dataset
uspto-grants-2008_02
Patent number
US07332495B2

Reaction notes

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