Potassium Carbonate → HCID 69204050, compound

HRID 2055224Notes

Reaction equation

HRID 2055224 reaction equation
[ClH:1].Cl.[C:3]([CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH:19]([C:23]1[CH:30]=[CH:29][C:26]([CH2:27][Cl:28])=[CH:25][CH:24]=1)[C:20]([CH3:22])=[O:21].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[ClH:28].[ClH:1].[C:20]([NH:19][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][N:16]2[CH2:15][CH2:14][N:13]([CH2:12][CH2:11][C:3](=[O:10])[C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:18][CH2:17]2)=[CH:25][CH:24]=1)(=[O:21])[CH3:22]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 148705Acetamide, N-(4-(chloromethyl)phenyl)-HCID 23080534HCID 23080534, compound

Product 1

HCID 69204050HCID 69204050, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of N-benzoylethyl piperazine dihydrochloride (1.5 g, 5 mmol), 4-acetamino-benzylchloride (1.1 g, 6 mmol) and K2CO3 (3.2 g, 24 mmol) in 60 ml of acetone was treated according to general preparation 2 to give compound (IV-21) yield 65%, mp 238-240° C. M+ 351.

Workup

  1. additionwas treated
  2. customaccording to general preparation 2
  3. customto give compound (IV-21) yield 65%, mp 238-240° C

Sources & evidence

ORD record
ord-74f24b3dbac0400c89113e35cd6973d4
Source dataset
uspto-grants-2008_02
Patent number
US07332495B2

Reaction notes

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