Potassium Carbonate → HCID 86606199, compound

HRID 2055225Notes

Reaction equation

HRID 2055225 reaction equation
[ClH:1].Cl.[CH2:3]([N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH3:18][O:19][C:20]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][C:21]=1[CH2:22]Br.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[ClH:1].[ClH:1].[CH3:18][O:19][C:20]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][C:21]=1[CH2:22][N:15]1[CH2:16][CH2:17][N:12]([CH2:3][C:4]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)=[O:5])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 775162-(Bromomethyl)-1-methoxy-4-nitrobenzeneHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 86606199HCID 86606199, compoundYield 133.4%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of N-phenacyl piperazine dihydrochloride (1.7 g, 6.1 mmol), 2-methoxy-5-nitro-benzylbromide (1.5 g, 6.1 mmol) and K2CO3 (2.7 g, 19.5 mmol) in 40 ml of acetone was treated according to general preparation 2 to give 1.80 g of compound (IV-23), yield 60%. M+ 368.

Workup

  1. additionwas treated
  2. customaccording to general preparation 2

Sources & evidence

ORD record
ord-6b61515ba681472cacebd3a4844ff10a
Source dataset
uspto-grants-2008_02
Patent number
US07332495B2

Reaction notes

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