Potassium Carbonate → HCID 86606202, compound

HRID 2055227Notes

Reaction equation

HRID 2055227 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][Cl:7].[ClH:11].Cl.[CH2:13]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:15].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[ClH:7].[ClH:11].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][N:25]1[CH2:26][CH2:27][N:22]([CH2:13][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:15])[CH2:23][CH2:24]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 699943-Methoxybenzyl chlorideHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 86606202HCID 86606202, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 3-methoxybenzylchloride (0.5 g, 2.15 mmol), N-phenacyl piperazine dihydrochloride (0.6 g, 2.15 mmol) and K2CO3 (1.04 g, 7.52 mmol) in 30 ml of acetone was treated according to general preparation 2 to give 0.46 g of compound (IV-25), yield 54%. M+ 324.

Workup

  1. additionwas treated
  2. customaccording to general preparation 2

Sources & evidence

ORD record
ord-4d5c529af5484fae8219fea7d5bee01d
Source dataset
uspto-grants-2008_02
Patent number
US07332495B2

Reaction notes

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