Water → HCID 69202998, compound

HRID 2055232Notes

Reaction equation

HRID 2055232 reaction equation
[N+:1]([C:4]1[CH:33]=[CH:32][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]([C:17]([C:19]3[CH:28]=[CH:27][C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:30][CH3:31])[C:25]=4[Cl:29])[CH:20]=3)=[O:18])[CH3:16])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([O-])=O.O>[NH4+].[Cl-].[Fe]>[ClH:29].[ClH:29].[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]([C:17]([C:19]3[CH:28]=[CH:27][C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:30][CH3:31])[C:25]=4[Cl:29])[CH:20]=3)=[O:18])[CH3:16])[CH2:11][CH2:10]2)=[CH:32][CH:33]=1

Participants

5

Reactant 2

HCID 962WaterHCID 69202644HCID 69202644, compound

Product 1

HCID 69202998HCID 69202998, compoundYield 172.3%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 25517Ammonium ChlorideSolvent

Procedure

A mixture of reductive iron (0.36 g, 6.47 mmol) in 8.5 ml of 5% NH4Cl, N1-(4-nitrobenzyl)-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl]piperazine (IV-32) (0.5 g, 0.92 mmol) and water (10 ml) was stirred for 5 hours, and processed according to the procedure of example 12 to give 0.27 g of compound (IV-33), yield 60%, mp 206-8° C., M+ 437.

Sources & evidence

ORD record
ord-690fd6d4c75d407a92902e5beb28e020
Source dataset
uspto-grants-2008_02
Patent number
US07332495B2

Reaction notes

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