反应详情

To a mixture of pyrimidin-5-yl-methanol, DMAP and NEt3 was slowly added MsCl at 0° C. and the reaction mixture was stirred at room temperature for 3 h. The reaction mixture was extracted with water and dichloromethane. The organic phase was dried on Na2SO4, filtered and the solvent was evaporated. Silica gel column chromatography (Ethyl acetate/hexane 1:1) gave the title compound in 40% yield.

1. customat 0° C.
2. extractionThe reaction mixture was extracted with water and dichloromethane
3. customThe organic phase was dried on Na2SO4
4. filtrationfiltered
5. customthe solvent was evaporated