Indole-3-Carboxylic Acid → 5-Bromo-1'-(1H-indol-3-ylcarbonyl)spiro[indole-3,4'-piperidin]-2(1H)-one

HRID 2055550Notes

Reaction equation

HRID 2055550 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)[C:9](=[O:16])[NH:8][C:5]2=[CH:6][CH:7]=1.[NH:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19]([C:26](O)=[O:27])=[CH:18]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:11][CH2:12][N:13]([C:26]([C:19]4[C:20]5[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=5)[NH:17][CH:18]=4)=[O:27])[CH2:14][CH2:15]3)[C:9](=[O:16])[NH:8][C:5]2=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 69867Indole-3-Carboxylic AcidHCID 596575825-Bromospiro[indoline-3,4'-piperidin]-2-one

Product 1

HCID 596576125-Bromo-1'-(1H-indol-3-ylcarbonyl)spiro[indole-3,4'-piperidin]-2(1H)-one

Procedure

Following the general procedure I as described above, the acylation of 5-bromospiro[indole-3,4′-piperidin]-2(1H)-one with 1H-indole-3-carboxylic acid (commercially available), gave the title compound. ES-MS m/e (%): 424.3(M+H+).

Sources & evidence

ORD record
ord-a7df51b296974957868782c620969a53
Source dataset
uspto-grants-2008_02
Patent number
US07332501B2

Reaction notes

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